Radiation Therapy & Targeted Tumors

Tumor Microenvironment

The tumor microenvironment is created by the tumor and dominated by tumor-induced interactions. Although various immune effector cells are recruited to the tumor site, their anti-tumor functions are down regulated, largely in response to tumor-derived signals. A tissue microenvironment of developing tumor is comprised of proliferating tumor cells, the tumor stroma, blood vessels, infiltrating inflammatory cells and a variety of associated tissue cells. It is a unique environment that emerges in the course of tumor progression as a result of its interactions with the host.